局部谷氨酸二甲酸盐:对2019年新冠病毒后疾病的有希望的治疗方法,通过调节来治疗嗅觉功能障碍
Majed A Algarni1, Mohammed S Alharthi1, Fahad H Baali1
1Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.
American journal of rhinology & allergy
|June 4, 2025
概括
谷氨酸二酸盐 (GLD) 鼻治疗通过降低鼻水平,改善了COVID-19后患者的嗅觉功能. 虽然在统计学上显著,但这些改善并没有达到临床意义,因此需要进一步研究.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 嗅觉功能障碍是COVID-19后的一个常见和衰弱的症状.
- 鼻腔水平升高与病毒后嗅觉障碍有关.
- 谷氨酸二酸盐 (GLD) 正因其分离特性而受到研究.
研究的目的:
- 评估局部GLD在改善嗅觉功能的有效性.
- 为了确定GLD是否降低COVID-19后嗅觉功能障碍中的鼻水平.
- 评估GLD在嗅觉恢复中的潜在治疗作用.
主要方法:
- 这是一项双盲,安慰剂控制的试验,涉及66名COVID-19后嗅觉功能障碍的参与者.
- 随机分组接受1%的GLD溶液或0.9%的盐溶液安慰剂,每天三次通过鼻子给药,持续六个月.
- 嗅觉功能通过嗅探棒测试 (门,区分,识别) 和鼻水平测量来评估.
主要成果:
- 与安慰剂组相比,GLD组在嗅觉值,歧视和识别得分方面显示出统计学上显著的改善.
- 在GLD治疗组中,鼻水平显著降低.
- 观察到的嗅觉改善没有达到临床意义的门.
结论:
- 局部GLD通过减少鼻来证明其作为COVID-19后嗅觉功能障碍的治疗潜力.
- 需要进一步的研究来确定GLD在嗅觉恢复方面的临床相关性和长期疗效.
- GLD可能为管理嗅觉障碍提供了一种新的治疗途径.
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