一个密切的单细胞亲属揭示了聚合的多细胞性是动物进化的关键
Ruibao Li1,2, Jennah E Dharamshi3,2, Kyle Kwok1
1Department of Chemistry, Indiana University Bloomington, Indiana, USA.
bioRxiv : the preprint server for biology
|June 4, 2025
概括
动物的起源仍然不清楚,但在 Ministeria vibrans 等单细胞亲属中的聚合表明祖先的能力. 这种行为利用了关键的多细胞性基因,可能是由养和繁殖驱动的.
科学领域:
- 进化生物学是进化的生物学.
- 细胞生物学 细胞生物学
- 多细胞性的起源
背景情况:
- 动物从单细胞祖先进化复杂的多细胞性是一个关键的未解答的问题.
- 动物的单细胞亲属通过分裂,共细胞或聚合表现出简单的多细胞性.
- 聚合在历史上一直被忽视,但在现存的动物细胞和一些单细胞亲属中存在.
研究的目的:
- 为了研究单细胞动物相亲Ministeria vibrans.中的聚合.
- 确定聚合是否是动物多细胞化的潜在前体.
- 确定参与M. vibrans聚合的基因,并将其与动物多细胞性基因进行比较.
主要方法:
- 培养Ministeria与一个alphaproteobacterium振动在一起.
- 观察和描述M. vibrans聚合物的形成和稳定性.
- 在聚合过程中分析与细胞粘附,信号和转录调节有关的基因表达.
主要成果:
- 部振动形成稳定,均的聚合物,具有可重现的动力学.
- 在M. vibrans中,聚合利用了许多与动物多细胞性相关的同类基因.
- 该研究确定了细胞粘附,信号和转录调节的关键基因,这些基因在聚合过程中活跃.
结论:
- 动物的最后一个单细胞共同祖先很可能拥有聚合的能力.
- 单细胞祖先的聚合可能是由增强的养和性繁殖驱动的.
- 聚合代表了一条通往动物多细胞性进化的合理途径.
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