相关实验视频

Updated: Jan 18, 2026

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
10:59

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events

Published on: May 13, 2019

10.2K

重组RNA聚合酶II复合体,以便在体内复制感染性非编码RNA

Jie Hao, Zhuan Qin, Junfei Ma

    bioRxiv : the preprint server for biology
    |June 4, 2025
    PubMed
    概括

    这项研究揭示了必不可少的RNA聚合酶II (Pol II) 酶如何在体内重组成一个较小的7个子单元复合体,以转录病毒性RNA. 转录因子IIIA的一个特定变体促进了这种新型RNA-依赖RNA聚合酶活性.

    更多相关视频

    DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation09:26

    DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

    Published on: December 29, 2021

    4.8K
    Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase07:27

    Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

    Published on: April 29, 2010

    14.0K

    相关概念视频

    Eukaryotic RNA Polymerases00:58

    Eukaryotic RNA Polymerases

    RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
    All three eukaryotic RNAPs require specific transcription factors, of which the...
    26.8K
    Eukaryotic RNA Polymerases00:58

    Eukaryotic RNA Polymerases

    9.1K
    Transcription Initiation01:47

    Transcription Initiation

    Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
    The promoters and enhancers and their accessory proteins allow tight regulation of...
    20.4K
    RNA Polymerase II Accessory Proteins02:36

    RNA Polymerase II Accessory Proteins

    Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
    10.8K
    RNA Polymerase II Accessory Proteins02:36

    RNA Polymerase II Accessory Proteins

    3.8K
    Viruses with RNA Genomes01:29

    Viruses with RNA Genomes

    RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
    840