在CAG重复扩张过程中,DNA挤出大小决定了路径选择

相关实验视频

Updated: Jan 18, 2026

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
08:22

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

Published on: September 16, 2019

8.4K

Mayuri Bhatia, Ashutosh S Phadte, Anna Lakhina

    bioRxiv : the preprint server for biology
    |June 4, 2025
    PubMed
    概括

    DNA三重重复扩张导致神经退行性疾病. DNA挤出的大小决定了FAN1核酶或MutSβ途径是否修复它们,控制重复稳定性或扩张.

    更多相关视频

    Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion05:22

    Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion

    Published on: September 13, 2024

    1.2K
    Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules09:32

    Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

    Published on: April 12, 2019

    7.1K

    相关概念视频

    PCR01:32

    PCR

    Overview
    237.0K
    The Replisome03:01

    The Replisome

    DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
    The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
    38.1K
    Long-patch Base Excision Repair01:02

    Long-patch Base Excision Repair

    Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
    7.9K
    Nucleotide Excision Repair01:08

    Nucleotide Excision Repair

    Overview
    40.6K
    Sanger Sequencing01:57

    Sanger Sequencing

    DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
    773.3K