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Updated: Jun 12, 2025

High-throughput Purification of Affinity-tagged Recombinant Proteins
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High-throughput Purification of Affinity-tagged Recombinant Proteins

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在H3-H4八基体上RNA聚合酶II转录的结构基础

Cheng-Han Ho1, Kayo Nozawa1, Masahiro Nishimura1

  • 1Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

bioRxiv : the preprint server for biology
|June 4, 2025
PubMed
概括

H3-H4八基体允许比传统的核细胞体更有效地进行RNA聚合酶II (RNAPII) 转录. 这是在转录过程中通过H3-H4四分体的逐步分解机制实现的.

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Transcription Initiation01:47

Transcription Initiation

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Bacterial Transcription01:53

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Bacterial RNA Polymerase00:43

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Unlike eukaryotes, bacteria use a single RNA Polymerase (RNAP) to transcribe all genes. The different subunits of bacterial RNAPhave distinct functions. The multisubunit structure of the bacterial RNAP helps the enzyme to maintain catalytic function, facilitate assembly, interact with DNA and RNA, and self-regulate its activity.
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