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在雷特综合征中剖析甲基胺基酸受体7表达:对药物治疗的后果

Sheryl Anne D Vermudez, Geanne A Freitas, Mackenzie Smith

    bioRxiv : the preprint server for biology
    |June 4, 2025
    PubMed
    概括

    在有严重MECP2突变的雷特综合征患者中,甲本托普谷氨酸受体7 (mGlu7) 水平下降. 对mGlu7的阳性全调节器 (PAM) 减少了小鼠模型中的呼吸异常,表明了治疗潜力.

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