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Updated: Jan 18, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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诱导中度DNA损伤增强了巨核形成和血小板生产

Roelof H Bekendam1,2,3, Virginia Camacho1,2, Andrew P Stone1,2,4

  • 1Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts.

bioRxiv : the preprint server for biology
|June 4, 2025
PubMed
概括

聚ADP核糖聚合酶 (PARP) 抑制剂可能导致血小板数量低下. 然而,低剂量PARP抑制或中等程度的DNA损伤令人惊地增强了巨核形成,增加了血小板的产生.

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