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Updated: Jun 12, 2025

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
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Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System

Published on: August 1, 2016

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一种生成语言模型解码了mRNA设计的编码子选择的上下文约束

Marjan Faizi, Helen Sakharova, Liana F Lareau

    bioRxiv : the preprint server for biology
    |June 4, 2025
    PubMed
    概括

    一个新的语言模型Trias通过从数据中学习复杂的编码子使用规则来优化合成mRNA序列. 它提高了mRNA稳定性和蛋白质输出,优于现有的工具.

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