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相关概念视频

Genomics02:02

Genomics

37.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.6K
Polygenic Traits01:18

Polygenic Traits

66.6K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.4K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

552
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
552
Human Genetics01:28

Human Genetics

743
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
743
Multiple Allele Traits01:49

Multiple Allele Traits

35.0K
The Concept of Multiple Allelism
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相关实验视频

Updated: Sep 19, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

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一个更新的多基因索引存储库:扩展表型,新队列和改进的因果推理.

Robel Alemu1,2,3, Anastasia Terskaya4, Matthew Howell1

  • 1UCLA Anderson School of Management, Los Angeles, CA, USA.

bioRxiv : the preprint server for biology
|June 4, 2025
PubMed
概括

多基因索引存储库的版本2提供了改进的基于DNA的表型预测. 这次更新扩展了表型和数据集,提高了遗传研究的预测准确性和可解释性.

更多相关视频

Infinium Assay for Large-scale SNP Genotyping Applications
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Infinium Assay for Large-scale SNP Genotyping Applications

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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相关实验视频

Last Updated: Sep 19, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

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Infinium Assay for Large-scale SNP Genotyping Applications
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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科学领域:

  • 遗传学 遗传学 是一个
  • 生物信息学是一种生物信息学.
  • 生物医学科学 生物医学科学

背景情况:

  • 多基因索引 (PGIs) 是基于DNA的重要工具,用于预测个体表型.
  • 现有的存储库需要更新以扩大范围和方法论,以便更广泛地应用.

研究的目的:

  • 引入多基因索引存储库的版本2,增强其在生物医学和社会科学中的实用性.
  • 扩大表型和数据集的数量,并完善PGI构建方法.

主要方法:

  • 将存储库扩展到61个表型和20个数据集.
  • 利用更新的全基因组关联研究 (GWAS) 分析总结统计数据,对16种表型进行了分析.
  • 为基于家庭的分析和开发的解释框架,纳入了指定的家长PGI.

主要成果:

  • 通过更新的GWAS数据,提高PGI预测能力.
  • 增加表型和参与者队列的覆盖范围.
  • 增强了减少混偏差和改善遗传分析中可解释性的工具.

结论:

  • 多基因索引存储库的版本2在PGI预测准确性和范围方面取得了重大进展.
  • 这些更新有助于进行更强大,更易于解释的遗传关联研究.
  • 这种增强的资源支持多基因索引在研究中的更广泛应用.