支持工作记忆能力和主动控制之间的关系的神经机制.
Rebecca Feldman1, Maya Quale1, Joset Etzel1
1Department of Psychological and Brain Sciences, Washington University in St. Louis.
bioRxiv : the preprint server for biology
|June 4, 2025
概括
工作记忆容量 (WMC) 与通过神经回路的主动控制有关,该神经回路涉及右背侧前额皮质和左运动皮质. 这个电路有助于将目标转化为行动准备,可能有助于认知增强.
科学领域:
- 认知神经科学 认知神经科学
- 神经成像是一种神经成像.
- 个人差异 个人差异
背景情况:
- 之前的研究表明,工作记忆容量 (WMC) 和主动控制之间存在联系.
- 这种关系的神经支仍然不清楚.
- 认知控制的双重机制 (DMCC) 项目为研究提供了合适的数据集.
研究的目的:
- 调查WMC和主动控制之间的关系背后的神经机制.
- 识别特定的大脑区域和电路,参与将认知目标转化为行动准备.
- 探索针对这些神经通路的认知增强的潜力.
主要方法:
- 利用了DMCC项目 (N > 100) 的fMRI数据,并进行了评估主动和反应控制的任务.
- 使用AX-CPT范式测量目标准备 (A-cue偏差指数) 的行为分析.
- fMRI分析将行为测量与特定大脑区域 (rDLPFC,lMOT) 的神经活动联系起来,并采用潜伏路径分析.
主要成果:
- 行为发现复制了先前的工作,显示A-cue偏差与主动控制增加并与WMC相关.
- fMRI数据显示,A-cue偏差与左运动皮层 (lMOT) 活动增加有关.
- WMC与右背侧前额叶皮层 (rDLPFC) 活动增加相关,潜在路径分析支持rDLPFC-lMOT电路在调解WMC-A-cue偏差关系中的作用.
结论:
- rDLPFC-lMOT神经电路优先调解WMC和主动控制之间的关系.
- 这个电路将战略任务目标转化为响应准备,这是主动控制的关键机制.
- 这个电路中的个体差异表明了潜在的认知增强策略.
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