rhesus macaques 中的 SIV/SARS-CoV-2 同感染会影响病毒分泌,宿主免疫力,微生物组和病毒进化
Megan N Fredericks1,2, Zohar Kolodner1,2, Adam Waalkes3
1Department of Microbiology, University of Washington, Seattle, WA, United States.
Frontiers in immunology
|June 4, 2025
概括
猿类免疫缺陷病毒 (SIV) 在的感染损害了对SARS-CoV-2的免疫反应,导致长期的病毒分泌和进化. 这种SIV/SARS-CoV-2共感染模型突出显示了HIV.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 携带艾滋病毒的人 (PLWH) 面临严重COVID-19的更高风险.
- 了解HIV/SARS-CoV-2共感染对于公共卫生至关重要.
- 猿类免疫缺陷病毒 (SIV) 模型为HIV/SARS-CoV-2相互作用提供了洞察力.
研究的目的:
- 为了研究SIV模型的HIV/SARS-CoV-2共感染.
- 评估SIV对SARS-CoV-2病原,免疫和病毒演变的影响.
- 评估该模型对研究共感染的有用性.
主要方法:
- 七只SIV阳性 rhesus同时感染了SARS-CoV-2.
- 对病毒复制,抗体和T细胞反应以及微生物群落进行了监测.
- 分析了SARS-CoV-2在上呼吸道中的演变.
主要成果:
- 所有的COVID-19病例均为轻微的.
- 在14天内,SARS-CoV-2在上呼吸道中复制.
- 观察到抗SARS-CoV-2抗体和T细胞生成受损.
- 在上呼吸道和胃肠道中发生过渡性微生物变化.
- 检测到SARS-CoV-2进化的证据.
结论:
- 在中SIV/SARS-CoV-2共感染反映了PLWH中COVID-19的方面.
- SIV 损害了抗SARS-CoV-2 免疫力,可能导致长时间的分泌和病毒演变.
- 这种模型对于研究HIV/SARS-CoV-2共感染及其影响非常有价值.
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