多基因和多基因x创伤对酒精使用和黑人美国人的问题作出贡献
Chelsie E Benca-Bachman1,2, Samantha Cassidy1,3, Rameez A Syed1
1Behavioral Genetics of Addiction laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
medRxiv : the preprint server for health sciences
|June 4, 2025
概括
患有酒精使用障碍 (AUD) 的基因风险较高的个体在暴露于终身创伤时,酒精消费和问题增加. 针对创伤的干预措施对于那些有AUD遗传风险的人来说至关重要.
科学领域:
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 童年虐待和终身创伤与酒精消费和问题有关.
- 遗传倾向可能与创伤等环境因素相互作用,影响饮酒行为.
研究的目的:
- 研究多基因风险和基因环境相互作用对饮酒和饮酒问题的贡献.
- 在黑人成年人童年虐待和终身创伤的背景下检查这些关系.
主要方法:
- 利用多个线性回归模型来预测酒精消费和问题.
- 从全基因组关联数据中获得创伤相关症状和酒精使用障碍 (AUD) 的多基因分数 (PGS).
- 包括年龄,性别,教育,就业状况和祖先主要组成部分等共变量.
主要成果:
- 童年虐待和终身创伤与酒精消费和问题都有积极的关联.
- 重新经历和避免创伤症状的多基因分数与增加的酒精问题有关.
- 终身创伤和AUD遗传风险之间的相互作用,以及创伤和过度兴奋遗传风险之间的相互作用,与较高的酒精问题得分有关.
结论:
- 对AUD的遗传风险增加加剧了终身创伤暴露的个体的酒精消费和问题.
- 建议针对遗传风险和创伤暴露的干预措施适用于AUD风险较高的人.
- 这些发现突出了饮酒中遗传脆弱性和环境压力因素之间的复杂相互作用.
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