使用乳酸脱酶作为登革热患者的预后标志物的观察性研究
Harish Kasarabada1, Sreenivasa S Iyengar2, Deependra Singh3
1Graded Specialist (Internal Medicine), INHS Kalyani, Visakhapatnam, India.
Medical journal, Armed Forces India
|June 4, 2025
概括
血清乳酸脱酶 (LDH) 水平可以预测登革热的严重程度. 登革热患者的LDH升高表明并发症风险较高,有助于早期医疗干预.
科学领域:
- 热带医学是一种热带医学.
- 传染病 传染病 传染病
- 生物标志物研究的研究.
背景情况:
- 登革热是印度南部的蚊子传播疾病,特别是在季风季节.
- 高发病率和死亡率需要改进的方法来预测登革热的严重程度.
- 内部医学部门启动了一项研究,以探索乳酸脱酶 (LDH) 作为登革热的预测生物标志物.
研究的目的:
- 调查血清乳酸脱酶 (LDH) 水平作为预测登革热感染严重程度的生物标志物.
- 为了将LDH水平与疾病并发症和死亡率相关联.
- 在登革热患者中确定及时医疗干预的早期指标.
主要方法:
- 进行了一项观察性,前性,单心研究.
- 包括2022年6月至2022年12月血清学证实登革热感染的患者.
- 在患者呈现时测量血清LDH水平.
主要成果:
- 在LDH水平和登革热严重程度之间观察到显著的正线性相关性 (皮尔森的R=0.778,P<0.01).
- 在入院时,LDH水平与血小板计数呈反向关系 (皮尔森R = -0.326).
- 呈现时较高的LDH水平与并发症风险增加有关.
结论:
- 诊断时的血清LDH水平作为预测登革热严重程度的可靠生物标志物.
- 监测LDH水平可以帮助预测和管理登革热患者的潜在并发症.
- 这种生物标志物有助于风险分层和优化患者管理,以减少死亡率.
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