白质微观结构在统计上调解了日间休息/活动节奏与老年人认知之间的关联
Daniel D Callow1, Corinne Pettigrew2, Vadim Zipunnikov3
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
概括
老年人的昼夜节律受损与较差的认知功能有关. 这项研究发现,更好的休息/活动节奏和白质完整性与老年大脑的执行功能保持有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 时间生物学 时间生物学
背景情况:
- 衰老与中断的昼夜节律,减少白质完整性和认知能力下降有关.
- 白质完整性在连接昼夜节律功能障碍与认知衰老中的作用尚不清楚.
研究的目的:
- 调查日间休息/活动节奏 (RARs),白质完整性 (分数异质性 - FA) 和老年人执行功能之间的关联.
- 为了确定白质完整性是否调解昼夜节律和认知表现之间的关系.
主要方法:
- 来自BIOCARD研究的156名老年人 (平均年龄71.3) 的横截面研究.
- 动图被用来评估RARs (相对幅度[RA],日间稳定性[IS],日内可变性[IV]).
- 评估了全脑FA和执行功能,并根据年龄,性别,教育,APOE-e4和血管风险等共变量进行调整.
主要成果:
- 较大的节奏强度 (RA) 与更好的执行功能有关.
- 更高的RAR强度 (RA) 和稳定性 (IS) 与更大的全脑FA (更好的白质完整性) 相相关.
- 较大的节奏碎片化 (IV) 与较低的FA相关. 白质完整性调解了RA与执行功能之间的关联.
结论:
- 循环节律的强度和稳定性与老年人的白质完整性和执行功能有关.
- 白质完整性可能是关键的机制,将昼夜节律调节与衰老期间的认知健康联系起来.
- 这些发现强调了维持健康的昼夜节律对于晚年认知健康的重要性.
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