预先存在的症状增加了在SARS-CoV-2大流行期间患长期COVID的风险
Vincent Lak1,2, Helen Sjöland1,2, Martin Adiels1,3
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Journal of internal medicine
|June 4, 2025
概括
被诊断为长期COVID的个人在感染SARS-CoV-2之前经常经历了相关症状. 这项研究发现,在长期COVID患者中,预先存在的症状的患病率更高,这表明存在潜在联系.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 长期COVID,以SARS-CoV-2感染后的持续症状为特征,构成了重大的公共卫生挑战.
- 了解长期COVID的起源和风险因素对于有效的管理和预防至关重要.
研究的目的:
- 在正式诊断之前调查与长期COVID相容的症状的患病率.
- 为了确定被诊断为长期COVID的个体是否在大流行之前表现出相关症状.
主要方法:
- 一项回顾性观察研究分析了来自Västra Götaland地区 (2020-2023) 的医疗保健数据.
- 国际疾病分类第10版 (ICD-10) 代码用于识别长期COVID,症状和SARS-CoV-2感染状态.
- 在长期COVID和非长期COVID队列之间比较了大流行前的症状数据 (2016-2019).
主要成果:
- 在1,415,885人中,0.6%的人被诊断为长期COVID.
- 在2020年1月1日之前,长期COVID患者 (57.6%的男性,71.6%的女性) 比对照组更常见的症状.
- 相关的流行前症状增加了长期COVID诊断的几率超过2.2倍的男性和女性,即使在调整并发症后.
结论:
- 在被诊断为长期COVID的个体中,在大流行之前,相关症状的负担更高.
- 这些发现表明,一些人可能有患长期COVID的倾向.
- 对先前存在的疾病及其在长期COVID病原发生中的作用进行进一步的研究是有必要的.
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