抗脂综合征中的外周神经病变:系统性审查
Rafael Reis do Espírito Santos1, Cezar Augusto Muniz Caldas1, Jozélio Freire de Carvalho2
1Faculty of Medicine, Federal University of Pará, Belém-Pará.
Reumatismo
|June 4, 2025
概括
周围神经病是抗脂综合征 (APS) 的罕见并发症,主要影响女性. 早期诊断和治疗,通常是用抗凝血剂和免疫抑制剂,导致大多数患者的积极结果.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 抗脂综合征 (APS) 是由复发性血栓和抗脂抗体来定义的.
- 周围神经系统疾病是APS不常见的表现.
- 在APS患者的外围神经病变 (PN) 需要系统的审查.
研究的目的:
- 在患有抗脂综合征 (APS) 的患者中系统地审查报告的周围神经病变 (PN) 病例.
主要方法:
- 在PubMed上进行了系统的文献搜索,寻找1966年至2022年8月发表的PN和APS的文章.
- 包括的文章有英语摘要.
主要成果:
- 确定了10篇文章,详细介绍了100名患有PN的APS患者.
- 患者主要是女性 (86-100%),年龄在25-78岁之间.
- 多重单核炎和自主神经病变是常见的临床表现;神经活检始终呈阳性,大多数患者通过抗凝剂,葡萄糖皮质类药物或免疫抑制剂得到改善.
结论:
- 周围神经病是抗脂综合征的一种罕见但已知的并发症.
- 在APS中PN主要影响女性,并与抗脂抗体阳性相关.
- 电神经图或神经活检确认和及时治疗与良好的结果相关.
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