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炎症性肠病中的基因环境相互作用:人类流行病学研究的系统审查
Jingjing Bai1, Dianne Gelien Bouwknegt1, Rinse Karel Weersma1
1Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Journal of Crohn's & colitis
|June 4, 2025
概括
基因与环境的相互作用会影响炎症性肠病 (IBD) 的风险. 这次审查发现了显著的基因吸烟和基因饮食相互作用,突出了基于遗传资料的个性化生活方式建议的需要.
科学领域:
- 遗传学 遗传学 是一个
- 环境健康 环境健康
- 胃肠病学 胃肠病学
背景情况:
- 复杂的基因环境相互作用 (GXE) 对于理解炎症性肠病 (IBD) 病因至关重要.
- 目前关于IBD中GXE的证据是分散的,需要进行全面的审查.
研究的目的:
- 系统地审查和总结有关炎症性肠病 (IBD) 中基因环境相互作用的现有证据.
主要方法:
- 在PubMed,EMBASE,Web of Science和Scopus进行系统的文献搜索,直到2024年4月.
- 包括检查IBD遗传变异和环境因素的研究.
- 使用STREGA指南对符合条件的研究进行分级.
主要成果:
- 在4833个已识别的出版物中,包括39个符合条件的研究,其中17个报告了显著的GXE.
- 经常研究NOD2吸烟相互作用,显示出对克罗恩病风险的变异特异性影响.
- 在IBD风险,解毒和吸烟相关基因以及炎症类细胞因子中发现了显著的基因吸烟相互作用.
- 全基因组相互作用分析发现了64种吸烟相互作用变体.
- 观察到各种营养素的基因饮食相互作用,包括脂肪酸,,,酒精,血红铁和维生素D.
结论:
- 肠道炎症的环境因素风险是由个体遗传变异调节的.
- 进一步的全基因组环境相互作用研究和基于基因型的试验至关重要.
- 基于遗传背景的个性化生活方式和饮食建议是IBD管理所需的.
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