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Updated: Sep 19, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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基于148个错误突变引起的p53功能障碍的结构机制的调查,使用AlphaFold3和分子动力学模拟

Kh R Rustamov1, J I Razzokov2,3, A Y Baev1,4

  • 1Laboratory of Experimental Biophysics, Center for Advanced Technologies, Tashkent 100174, Uzbekistan.

Journal of chemical information and modeling
|June 4, 2025
PubMed
概括

瘤蛋白p53 (TP53) 突变通过改变其DNA结合而影响癌症. 计算方法揭示了特定TP53变异如何影响稳定性和功能,为癌症治疗提供了洞察力.

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