在一般人群中,基于囊素C和基于肌素的估计淋巴膜过率和死亡率之间的不一致
Qiaoling Liu1,2, Carlos Celis-Morales1,3,4, Jennifer S Lees1
1School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.
Clinical chemistry
|June 4, 2025
概括
基于囊素C (eGFRcys) 和基于肌素 (eGFRcr) 估计的淋巴细胞过率之间的差异很常见,并且与一般人群的死亡风险有关. 较低的eGFRcys表示死亡风险更高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 估计的膜过率 (eGFR) 对于评估功能至关重要.
- 基于囊素C (eGFRcys) 和基于肌素 (eGFRcr) 的eGFR之间的不一致越来越被认可.
- 在一般人群中,eGFR异常与全因死亡率的关联仍未得到充分研究.
研究的目的:
- 在大量的一般人群中调查eGFR异常的患病率.
- 检查eGFR异调与全因死亡率之间的关联.
主要方法:
- 利用了来自325,356名参与者 (40-69岁) 的英国生物库数据.
- 使用CKD-EPI和EKFC方程计算的eGFR,用于囊素C和肌素.
- 基于绝对 (±15 mL/min/1.73 m2) 和相对 (eGFRcys < 60% eGFRcr) 差异的定义不一致.
- 采用多变量Cox比例危险模型来估计死亡风险.
主要成果:
- 15.5%的参与者表现出不一致的较低绝对eGFRcys;8.5%表现出不一致的较高绝对eGFRcys.
- 不一致的较低EGFRcys与年龄较大,男性性别,较高的BMI,较高的血压,更多的并发症和较少的体力活动有关.
- 患有不一致的低GFRcys的参与者死亡风险增加了53% (HR=1.53).
- 那些具有不一致的高EGFRcys的人有30%的较低死亡风险 (HR=0.70).
- 较低相对EGFRcys的不一致性使死亡风险增加了一倍 (HR=2.25).
结论:
- 在一般人群中,eGFR不一致性很普遍.
- eGFR失调与所有原因的死亡率有显著的关联.
- 基于cystatin C的eGFR可能会改善死亡风险分层.
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