在接受癌症手术的脆弱患者的预康复:系统性审查和元分析
Zirong Bai1,2, Cherry Koh1,2,3, Michael Solomon1,2,3
1Surgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital (RPAH), Camperdown, Sydney, NSW, Australia.
Annals of surgical oncology
|June 4, 2025
概括
在脆弱的癌症患者中,预康复显著减少了任何术后并发症. 然而,由于证据有限,其对重大并发症和住院时间的影响需要进一步调查.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 外科手术的结果
背景情况:
- 有限的证据存在于脆弱的癌症患者的预康复.
- 预康复旨在改善患者在手术前的结果.
研究的目的:
- 系统地审查和对脆弱癌症患者预康复疗法的有效性进行元分析.
- 评估的主要结果是术后并发症和住院时间 (LOS).
主要方法:
- 进行全面的数据库搜索 (MEDLINE,Embase,Cochrane等) 在2023年12月之前.
- 包括5项随机对照试验 (RCT),共466名患者.
- 随机效应的元分析用于计算相对风险 (RR) 和平均差异 (MD) 使用95%置信区间 (CI).
主要成果:
- 预康复减少了任何术后并发症 (RR = 0.82;95% CI = 0.71-0.95).
- 在重大术后并发症方面没有发现显著影响 (RR = 0.89;95% CI = 0.71-1.11).
- 住院时间 (LOS) 没有显著影响 (MD = 0.3;95% CI = -0.68至1.28).
结论:
- 前期康复治疗显著降低了脆弱癌症患者手术后并发症的总体发生率.
- 由于缺乏足够的证据,对于重大术后结果的预康复疗法的有效性仍然不清楚.
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