在REM睡眠行为障碍-莱维体疾病连续体中的血液微生物群签名
Ryul Kim1, Sujin Oh2, Kyung Ah Woo2
1Department of Neurology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
概括
血液微生物组在勒维体疾病 (LBD) 中不同,特定的细菌转移被确定. 这些血液微生物群签名可以作为生物标志物来诊断REM睡眠行为障碍 (RBD) -LBD连续.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 微生物群变化的系统性炎症是莱维体疾病 (LBD) 提出的一种机制.
- 血液微生物组与LBD之间的关联,包括REM睡眠行为障碍 (RBD),尚不清楚.
研究的目的:
- 为了研究整个RBD-LBD连续性的血液微生物组概况.
- 探索血液微生物群签名作为疾病表型和临床严重性的生物标志物的潜力.
主要方法:
- 来自106名患者的血液样本的16S rRNA元基因组测序 (孤立的RBD,患有RBD的帕金森病,患有RBD的勒维体痴呆症) 和94名对照.
- 使用运动障碍学会统一的帕金森病评级表 (MDS-UPDRS) 和神经心理测试来评估临床严重程度.
主要成果:
- 与对照组相比,在RBD-LBD连续组中观察到显著的微生物转移,减少的α多样性和明显的β多样性模式.
- 在RBD-LBD连续体中,观察到斯坦诺托福蒙的丰富和阿西托巴克特,恩希德罗巴克特和乳酸菌的枯竭.
- 使用这些属的预测模型实现了RBD-LBD连续的高精度 (AUC 0.970),并区分了孤立的RBD (AUC 0.956).
- 微生物多样性与MDS-UPDRS部分I和II分数有显著的相关性.
结论:
- 在RBD-LBD连续体内的患者表现出鲜明的血液微生物体特征.
- 血液微生物组资料显示,它们有可能成为RBD-LBD连续和疾病严重程度的非侵入性生物标志物.
更多相关视频
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
6.0K
07:56Author Spotlight: Developing Photo-Stimulation Technology for Toxin Removal in Sleep-Related Brain Diseases
Published on: June 28, 2024
1.3K
相关概念视频
01:15REM Sleep Behavior Disorder
1.4K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
1.4K
01:24Sleep-Wake Cycles
2.7K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.7K
01:22Stages of Sleep
1.3K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.3K
01:37Neural Regulation
43.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.2K
01:27Restless Leg Syndrome and Night Terrors
494
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
494
01:17Sleepwalking and Sleep Talking
899
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
899