在非酒精性脂肪性肝病患者中循环纤维细胞生长因子-21:系统性审查和元分析
Ioanna Filimidou1, Myrsini Orfanidou2, Antonis Goulas2
1First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. ifilimidou@gmail.com.
Current obesity reports
|June 4, 2025
概括
与对照组相比,非酒精性脂肪性肝病 (NAFLD) 患者的循环纤维细胞生长因子-21 (FGF-21) 水平较高. 这种增加与非酒精性脂肪肝炎 (NASH) 和肝硬化等晚期疾病有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 的发病过程非常复杂.
- 纤维细胞生长因子-21 (FGF-21) 在NAFLD中的作用是有争议的,因为数据相互矛盾.
研究的目的:
- 合成并比较NAFLD患者与对照者的循环FGF-21水平.
- 澄清FGF-21和NAFLD严重程度之间的关联.
主要方法:
- 在PubMed,Cochrane图书馆和Scopus进行了全面的文献搜索.
- 对44项有15563名参与者的观察性研究进行了元分析.
- 亚组和元回归分析以评估异质性.
主要成果:
- 与对照组相比,NAFLD患者的FGF-21水平明显高于对照组 (SMD:0.61,p < 0.00001).
- 在非酒精性脂肪肝炎 (NASH) 和与NASH相关的肝硬化中,FGF-21的升高显著.
- 2型糖尿病患病率解释了异质性的很大一部分.
结论:
- 循环的FGF-21是NAFLD的潜在生物标志物,特别是晚期.
- 较高的FGF-21水平与疾病严重程度相关,包括NASH和肝硬化.
- FGF-21的升高可能反映了NAFLD的疾病进展.
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