在神经病痛中miRNAs作用的知识结构,研究热点和新兴趋势:使用Python进行定量分析
Kun Wang1, Xianfeng Qiu2, Pan Fan3
1Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Molecular neurobiology
|June 4, 2025
概括
这项研究分析了神经病痛中的微RNA (miRNA) 研究,发现出版物激增,并确定了关键趋势. miRNAs显示出作为诊断生物标志物和神经疼痛治疗点的前景.
科学领域:
- 生物医学研究的研究.
- 遗传学 是一个遗传学.
- 疼痛管理 疼痛管理
背景情况:
- 神经病痛是一种复杂的慢性疾病,治疗选择有限.
- 微RNAs (miRNAs) 是参与疼痛调节的基因表达的关键调节者.
- 了解miRNA的作用对于开发新的神经病痛治疗方法至关重要.
研究的目的:
- 确定miRNA相关的神经病痛研究的研究热点和趋势.
- 突出miRNAs作为诊断生物标记物和治疗点的潜力.
- 提供当前研究和该领域未来方向的概述.
主要方法:
- 从科学网数据库中对2009-2024年期间的394篇文章进行了图书统计分析.
- 利用Python分析协作,关键字突发事件,引用趋势和集群.
- 评估国家,机构和个人研究人员的研究贡献.
主要成果:
- 从2019年到2022年,出版物显著增加,中国,美国和德国是主要贡献者.
- 关键的研究领域包括初级感觉神经元,细胞亡,生物信息学,脊髓损伤和生物标志物.
- 确定了诸如狭窄的焦点,孤立的途径,有限的标准化和过度依赖动物模型等挑战.
结论:
- 神经性疼痛的miRNA研究正在迅速扩大,对诊断和治疗有很大的潜力.
- 未来的方向包括探索监管网络,相互连接的途径,标准化的协议和临床试验.
- 本综述提供了一个全面的前景,以指导研究人员和临床医生开发基于miRNA的先进策略来治疗神经病痛.
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