严重死性筋膜炎的增加 - - 这是COVID-19大流行的另一个后果?
Alexander Eijkenboom1, Jan Friederichs1, Simon Hackl1,2
1Department of Trauma and Orthopedic Surgery, BG Unfallklinik Murnau, Professor-Küntscher-Straße 8, 82418, Murnau am Staffelsee, Germany.
Infection
|June 4, 2025
概括
随着COVID-19的限制,死性筋膜炎 (NF) 病例,特别是由Streptococcus pyogenes引发的II型,在流行后显著增加. 这表明人口中的"免疫债务",导致对严重感染的易感性增加.
科学领域:
- 传染性疾病 传染性疾病
- 创伤外科 手术 创伤外科
- 流行病学 流行病学
背景情况:
- 德国实施了COVID-19大流行限制,包括面具强制和社交距离.
- 在取消这些措施后,发现A组链球菌感染的增加,特别是死性带炎 (NF).
- 了解NF发病率和类型的变化对于公共卫生和临床管理至关重要.
研究的目的:
- 评估COVID-19大流行之前,期间和之后的I型和II型死性膜炎 (NF) 的发生率.
- 在这些时期内分析NF患者人口统计和临床特征的变化.
- 调查与流行病相关的限制对NF流行病学的潜在影响.
主要方法:
- 在2010年至2023年期间在1级创伤中心治疗的165名严重NF患者的回顾性分析.
- 根据相对于COVID-19限制的入院日期,患者被分为口罩前,口罩后和口罩后的组.
- 评估了临床参数和患者特征,并在各组之间进行了比较.
主要成果:
- 第一种类型的NF在流行前 (69%) 更为普遍,而第二种类型的NF在面具期间 (95%) 占主导地位,并在流行后 (74%) 显著增加.
- 与口罩前和口罩期间相比,在口罩后组观察到Streptococcus pyogenes触发的II型NF显著增加 (p < 0.001).
- 后面具时代的NF患者年轻,看起来更健康,而不是早期的患者.
结论:
- 这项研究支持了这一观点.
- 免受债务免疫的债务.
- 这是一个假设,表明流行后人口免疫力下降有助于增加NF发病率.
- 由于Streptococcus pyogenes驱动的II型死性纤维炎的增加是一个显著的限制后趋势.
- 这些发现突显了在重大公共卫生干预后传染病的不断变化的格局.
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