免疫疗法和放射疗法在治疗算法中的整合,用于局部发达的状细胞皮肤癌
Ioannis M Koukourakis1, Antonios Karpouzis2, Konstantinos Filippatos3
1Radiation Oncology Unit, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens (NKUOA), Athens, Greece.
Medical oncology (Northwood, London, England)
|June 4, 2025
概括
这项研究表明,将前期免疫疗法与塞米普利马布和放射疗法结合起来,可以有效地治疗局部发达状细胞皮肤癌 (LA-sqCSC). 这种方法实现了较高的完全响应率,并改善了患者的生存结果.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 局部发达的状细胞皮肤癌 (LA-sqCSC) 由于瘤大小和患者因素,对激进放射治疗提出了挑战.
- 复发的LA-sqCSC通常需要除了手术之外的替代治疗策略.
研究的目的:
- 评估LA-sqCSC.联合治疗算法的疗效.
- 评估LA-sqCSC患者的前期免疫疗法随后放射治疗的结果.
主要方法:
- 30名LA-sqCSC患者接受了前期塞米普利马布 (抗PD-1) 免疫疗法和同时进行放射治疗.
- 患有残留疾病的患者接受了局部低分离放射治疗 (6x6 Gy),同时接受了塞米普利马布.
- 完全响应的人继续服用塞米普利马布长达18个月.
主要成果:
- 综合算法的整体完整响应率为70.0%.
- 前期免疫疗法实现了50.0%的完全响应率.
- 预计的2年无进展生存率为68.4%,疾病特异性总生存率为85.2%.
结论:
- 前期的塞米普利马布免疫疗法,然后是短期的低分离放射疗法是LA-sqCSC的有效治疗方法.
- 这种综合方法为晚期皮肤癌患者提供了有希望的生存益处.
相关概念视频
Tumor Immunotherapy
675
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
675
Skin Cancer
4.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.6K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
Cancer Vaccines
522
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
522


