产前和儿童感染以及风险
Yi-Jiun Pan1, Mei-Chen Lin2, Chi-Fung Cheng2
1Department of Microbiology and Immunology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
European journal of epidemiology
|June 4, 2025
概括
怀孕期间母亲感染与儿童有关,但这可能是由于家族病史. 然而,早期儿童感染显示出与风险增加的潜在因果关系.
科学领域:
- 流行病学 流行病学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 怀孕期间和生命早期的感染被怀疑是的危险因素.
- 以前的研究往往无法充分控制家族性倾向,这是一个潜在的混因素.
研究的目的:
- 评估与子宫内和儿童早期感染相关的风险.
- 用基于人口和兄弟姐妹的比较分析来区分家族混和感染的潜在因果作用.
主要方法:
- 在台湾进行全国范围的出生队列研究 (2001年至2016年为2,609,289人).
- 确定的孕产妇在怀孕期间的感染和早期儿童感染 (生命的第一年).
- 使用兄弟姐妹比较分析来考虑未测量的家族因素;孕前母亲感染作为负对照.
主要成果:
- 人口分析显示,怀孕期间母亲感染的风险增加 (HR=1.36),但在兄弟姐妹分析中 (HR=1.11),除了败血症和中枢神经系统感染外,这种风险减弱了.
- 孕前母亲感染在人口分析中显示出关联,但在兄弟姐妹分析中没有,这表明了家族混.
- 在人口 (HR=1.49) 和兄弟姐妹 (HR=1.31) 分析中,早期儿童感染始终与风险增加有关.
结论:
- 怀孕期间母亲感染和后代风险之间的关联在很大程度上归因于家族混因素.
- 在幼儿时期发生的感染似乎在随后的发育中发挥了更直接的,潜在的因果作用.
更多相关视频
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.5K
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
1.8K
相关概念视频
Epilepsy and Seizures: Overview
297
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
297
Seizures: Classification
620
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
620
Biological Causes of Schizophrenia
156
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
156
Disorders of the Nervous Tissue
1.7K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.7K
Causality in Epidemiology
920
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
920
