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黑色素瘤和孕妇:一个系统审查和元分析

Michele Kreuz¹, Pedro Henrique de Souza Wagner², Larissa E Tanimoto³

¹Department of Medicine, Lutheran University of Brazil, Canoas.

Melanoma research

|June 4, 2025

概括

分析了与怀孕相关的黑色素瘤结果,发现怀孕妇女的整体存活率 (OS) 比非怀孕妇女高. 然而,两组之间在黑色素瘤复发率或死亡率方面没有发现显著差异.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
生殖医学生殖医学

背景情况:

黑色素瘤可以发生在怀孕期间或产后一年.
关于怀孕对黑色素瘤存活率,复发率和死亡率的影响的证据有限.
怀孕相关的黑色素瘤需要进一步调查其临床影响.

研究的目的:

系统地审查和分析孕妇与非孕妇的黑色素瘤存活率,复发率和死亡率.
为了比较患有黑色素瘤的孕妇和非孕妇之间的整体存活率 (OS).
评估这些群体之间黑色素瘤复发率和死亡率的差异.

主要方法:

在Medline,Embase和Web of Science进行了系统的文献搜索.
包括比较孕妇和非孕妇黑色素瘤的研究.
危险比率 (HRs) 和风险比率 (RRs) 估计使用随机效应模型与RStudio 4.4.1.1.

主要成果:

分析包括15项研究,涉及29,095名患者 (10%怀孕).
孕妇的总体存活率 (OS) 在统计学上显著更高 (HR:0.81,95% CI:0.69-0.95,P=0.012).
在5年的生存期,黑色素瘤复发 (RR: 1.19,P=0.12) 或死亡率 (RR: 1.60,P=0.16) 中没有发现显著差异.

结论:

与非孕妇相比,被诊断患有黑色素瘤的孕妇的整体存活率似乎更好.
在这次元分析中,怀孕状态没有显著影响黑色素瘤复发率或死亡率.
需要进一步的研究,以了解怀孕和黑色素瘤预后之间的复杂相互作用.

关键词:

黑色素瘤是一种黑色素瘤.没有怀孕的非孕妇总体存活率总体存活率怀孕怀孕怀孕怀孕怀孕

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