Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Structural model of health-promoting behavior in middle-aged Korean women with hypertension based on the Information-Motivation-Behavioral Skills model: a cross sectional study.

Women's health nursing (Seoul, Korea)·2026
Same author

Upcycling food processing byproducts via advanced yeast fermentation.

Current opinion in biotechnology·2026
Same author

Programmable Double Peptide Nucleic Acid-Locked Nucleic Acid Molecular Switch Enables Extraction-Free Direct Zygosity Discrimination of Single Nucleotide Polymorphisms.

Analytical chemistry·2026
Same author

Roll-to-Roll Gravure-Printed SWCNT Ring Oscillator for Flexible Microfluidic Ion Sensing.

Nanomaterials (Basel, Switzerland)·2026
Same author

Metabolic engineering of Saccharomyces cerevisiae for redox-assisted co-fermentation of l-rhamnose.

Bioresource technology·2026
Same author

300-unit-per-second roll-to-roll manufacturing of visible metalenses.

Nature·2026

相关实验视频

Updated: Jan 18, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

7.7K

动态脂质体传感平台通过非接触感知无线确保核酸封装.

Younsu Jung1, Jinhwa Park1,2, Seonghun Shin3

  • 1Department of Biophysics, Institute of Quantum Biophysics, Research Engineering Center for R2R Printed Flexible Computer, Sungkyunkwan University, Suwon-si, 16419, Rep. of Korea.

Small (Weinheim an der Bergstrasse, Germany)
|June 4, 2025
PubMed
概括

一个新的动态脂质体传感平台使用带电子涂层的薄膜晶体管来监测含核酸的脂质体. 这种非接触式系统实现了高封装效率,这对于基因治疗和mRNA疫苗至关重要.

关键词:
滴滴微流体学 滴滴微流体学没有标签的 label-free.脂质体组是什么? 脂质体组是什么?卷对卷的滚动方式薄膜晶体管是一种薄膜晶体管.

更多相关视频

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

8.0K
Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.5K

相关实验视频

Last Updated: Jan 18, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

7.7K
The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

8.0K
Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.5K

科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术纳米技术
  • 材料科学 材料科学 材料科学

背景情况:

  • 在脂质体中核酸有效载荷的高通量,非接触式监测对于推进基因疗法至关重要.
  • 目前的方法可能缺乏效率或需要直接接触,限制了可扩展性.

研究的目的:

  • 开发一种新的动态脂质体传感 (DLs) 平台,以高效,非接触式监测DNA加载的脂质体.
  • 利用生物灵感设计提高脂质体分析的灵敏度和吞吐量.

主要方法:

  • 基于碳纳米管的单壁薄膜晶体管 (eSWCNT-TFT) 的实现.
  • 卷对卷 (R2R) 印刷SWCNT-TFT在塑料薄膜上,集成一个滴滴微流体芯片.
  • 监测由脂质体诱导的静电电位差异,以确定净电荷变化.

主要成果:

  • DLs平台通过测量值电压 (Vth) 在没有直接接触的情况下的变化来检测DNA载荷脂质体.
  • 实现了87.3 ± 3.2%的最大封装效率,每滴敏感度为18.61 nA ppm-1 .
  • 基于信使核糖核酸 (mRNA) 的疫苗在现场检查的可扩展性.

结论:

  • 开发的基于eSWCNT-TFT的DLs平台提供了一种高通量,非接触式的解决方案,用于监测脂质体中的核酸有效载荷.
  • 这项技术在基因疗法和疫苗生产中的质量控制方面具有重大潜力,特别是基于mRNA的产品.