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工程红细胞扩大瘤双气输血治疗双气输血治疗

Tao Li¹, Min Ouyang¹, Wei Wang¹

¹NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.

Advanced materials (Deerfield Beach, Fla.)

|June 4, 2025

概括

工程红细胞提供双重气体 (一氧化碳和氧化) 用于放大瘤治疗. 这种创新方法通过向瘤微环境来提高癌症治疗效率和生物安全性.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
纳米技术纳米技术

背景情况:

红细胞 (RBC) 对于输送氧气至关重要,可以携带一氧化碳 (CO) 和一氧化 (NO) 等治疗气体.
传统的气体捐赠者面临非特异性释放和生物安全方面的挑战,限制了临床气体治疗应用.
作为自然载体,红细胞提供了一个潜在的解决方案,以克服这些局限性.

研究的目的:

为扩大双气体 (CO和NO) 输血治疗瘤而设计红细胞.
研究瘤特异性过氧化 (H2O2) 激活气体释放的机制.
在瘤模型中评估工程红细胞的治疗疗效和生物安全性.

主要方法:

先进的纳米和气体工程技术被用来开发装有CO和NO的RBC.
工程化红细胞被设计为由瘤特异的H2O2激活,触发反应性氧物种 (ROS) 和反应性物种 (RNS) 放大.
瘤细胞膜工程被整合为有针对性的交付,结合αPD-L1的协同效应.

主要成果:

工程化红细胞成功地输送了CO和NO,由瘤H2O2.2激活.
释放的气体通过血红蛋白催化放大了ROS/RNS的产生 (ONOO-),破坏了瘤糖代谢.
该疗法重塑了瘤免疫抑制微环境并抑制了转移性瘤,显示出显著的治疗增强.
基于红细胞的工程疗法显示出出色的生物安全性.

结论:

工程化红细胞为扩大瘤的双气输血疗法提供了一个有希望的平台.
这种方法提供了有针对性的,个性化的癌症治疗,提高了疗效和生物安全性.
该研究强调了以RBC为基础的气体输送作为可翻译的癌症治疗模式的潜力.

关键词:

在CO和NO中,有 CO和NO.工程工程工程工程工程葡萄糖代谢恒常性恒常性红细胞 (红细胞) 是红细胞的组成部分.瘤气体输血疗法是瘤气体输血疗法.

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