β-上腺素受体在血管扩张中介于性别差异,但在缺氧期间不介于同情性血管收缩
Dain W Jacob1, Brian Shariffi1, Braden J Bond1
1Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
概括
贝塔-上腺素受体 (ARs) 在女性中介于缺氧血管扩张,但在男性中没有. 这些受体在任何两性中都不会影响缺氧期间的交感血管收缩.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的自主神经系统
- 在生理学的性别差异.
背景情况:
- 贝塔-上腺素受体 (ARs) 影响血管度,调解部分缺氧血管扩张和麻木交感血管收缩.
- 血管β-AR敏感性可能在女性中比男性更大,但它们在缺氧期间的具体作用尚不清楚.
研究的目的:
- 研究β-ARs在调解缺氧血管扩张和交感血管收缩方面的性别特异性作用.
- 测试β-AR阻塞会减弱缺氧血管扩张和增加交感血管收缩的假设,女性的影响更大.
主要方法:
- 十名女性和13名男性在随机盲目交叉设计中接受了安慰剂或普罗兰诺洛尔 (β-AR阻塞).
- 前臂血流 (FBF) 和血压 (BP) 在正常和稳定状态低氧期间被测量.
- 在正常和缺氧期间,通过冷压测试 (CPT) 评估了交感激活.
主要成果:
- 在女性中β-AR阻塞显著降低了缺氧血管扩张,但在男性中没有 (缺氧和性别的相互作用:P = 0.029).
- 与男性相比,女性在缺氧期间的交感血管收缩减弱 (性别的主要影响:P = 0.005).
- 在两性中,β-AR阻塞在缺氧期间没有影响交感血管收缩 (P > 0.238).
结论:
- β-上腺素受体在缺氧血管扩张中起作用,特别是在女性中.
- 在两性中,β-ARs在缺氧期间不会调节交感介导血管收缩.
- 这些发现突出了血管对缺氧反应的性别特异性机制.
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