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Updated: Jan 18, 2026

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
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An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation

Published on: June 30, 2015

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抑制NR2F2可以恢复激素治疗对内分泌耐受性乳腺癌的反应

Yanyan Cai1, Peihua Zhao2,3, Fan Wu1

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Science translational medicine
|June 4, 2025
PubMed
概括

神经纤维素1 (NF1) 的损失导致雌激素受体阳性乳腺癌的内分泌耐药性,通过增加核受体亚家族2组F成员2 (NR2F2). 抑制NR2F2恢复了激素治疗的敏感性,提供了一个新的治疗策略.

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