在欧洲移民人口中爆发的Corynebacterium diphtheriae疫情
Andreas Hoefer1, Helena Seth-Smith2, Federica Palma3,4
1European Center for Disease Prevention and Control, Solna, Sweden.
The New England journal of medicine
|June 4, 2025
概括
2022年欧洲喉病 (Corynebacterium diphtheriae) 爆发涉及363个孤立体,主要是移民中的皮肤感染. 检测到抗微生物耐药性基因,引发了治疗疗效方面的担忧.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 从2022年夏天开始,欧洲移民接待中心发生了Corynebacterium diphtheriae感染的显著增加.
- 疫情主要包括皮肤病例,还包括呼吸道感染和1例死亡病例.
- 成立了一个泛欧洲联盟,调查这次白喉疫情的临床,流行病学和微生物学的方面.
研究的目的:
- 评估在欧洲发生的有毒Corynebacterium diphtheriae疫情的临床,流行病学和微生物学特征.
- 分析受影响的移民种群中C. diphtheriae分离物的遗传多样性和抗菌素耐药性模式.
主要方法:
- 分析了来自10个欧洲国家的362名患者的363个有毒的C. diphtheriae分离物 (2022年1月至11月).
- 通过患者采访收集流行病学数据,包括原产国和过境路线.
- 全基因组测序和抗菌素敏感性测试,以评估家族遗传关系和耐药性基因.
主要成果:
- 疫情包括77.5%的皮质耳,15.3%的呼吸道耳和2.6%的混合症状.
- 鉴定出了四个不同的C. diphtheriae遗传群,这表明了多克隆的疫情,估计起源于2017年至2020年之间.
- 在一组分离物中发现了抗微生物耐药性基因 (ermX,pbp2m,blaOXA-2),这些基因对红红素和β-乳糖胺产生了耐药性.
结论:
- 从欧洲各地遗传集群的分布来看,C. diphtheriae的重复跨境传播是显而易见的.
- 移民中C. diphtheriae感染的高发病率令人担忧.
- 抗微生物耐药性表型的存在对当前一线白喉治疗的有效性构成重大威胁.
更多相关视频
08:23Culture Methods to Determine the Limit of Detection and Survival in Transport Media of Campylobacter Jejuni in Human Fecal Specimens
Published on: March 10, 2020
11.7K
05:25Author Spotlight: Expanding the Scope of Multiplex Immunoassays for Lyme Borreliosis Diagnostics and Pathogen Research
Published on: July 14, 2023
1.6K
相关概念视频
01:30Acute Pharyngitis
1.7K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
1.7K
01:23Chronic Pharyngitis
5.3K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
5.3K
01:17Transmission-based Precautions I: Contact, Enteric, and Droplets
4.1K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.1K
01:26Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
01:51Vaccinations
45.4K
Overview
45.4K
01:20Infection
8.8K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.8K