母亲糖尿病,抗糖尿病药物使用和需要住院护理的严重ADHD之间的联系:基于登记册的队列研究
Yitayish Damtie1, Kim Betts2, Berihun Assefa Dachew3
1School of Population Health, Faculty of Health Sciences, Curtin University, Australia; Department of Public Health, College of Medicine and Health Science, Injibara University, Injibara, Ethiopia.
孕妇糖尿病和怀孕期间使用抗糖尿病药物并没有增加儿童严重注意力缺陷/多动症障碍 (ADHD) 的风险. 需要进一步的研究来确认这些药物的长期神经发育安全性.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 药理学 药理学是指药理学的学科.
背景情况:
- 关于母亲使用抗糖尿病药物与儿童神经发育结果之间的联系的证据有限.
- 这项研究调查了母亲糖尿病,药物使用和后代严重的注意力缺陷/多动障碍 (ADHD) 之间的联系.
研究的目的:
- 检查怀孕期间母亲糖尿病与儿童严重ADHD风险之间的关联.
- 评估母亲使用抗糖尿病药物与后代ADHD风险之间的关系.
主要方法:
- 利用来自澳大利亚新南威尔士州的链接卫生行政数据.
- 使用ICD-10-AM代码识别了母糖尿病,抗糖尿病药物使用和后代ADHD.
- 采用二进制逻辑回归来计算调整的赔率比率 (AOR) 和95%置信区间 (CI).
主要成果:
- 分析了 229,785 个母子对. 分析了 229,785 个母子对.
- 母亲糖尿病 (任何,GDM,先前存在的) 与严重ADHD风险的增加没有关联 (例如,任何糖尿病AOR=1.10,95%CI:0.84-1.45).
- 怀孕期间使用抗糖尿病药物没有与ADHD有显著的联系 (OR=1.17,95%CI:0.66-2.06).
结论:
- 结果不支持假设,产前暴露于抗糖尿病药物独立增加严重的ADHD风险.
- 进一步的研究是必要的,以充分了解长期的神经发育安全的孕产妇抗糖尿病药物.
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