兴奋剂有助于改善肠道免疫力,并积极调节肠道微生物群在肉中死肠炎
Seyeon Chang1, Minho Song2, Jihwan Lee3
1Department of Animal Science, Chungbuk National University, Cheongju 28644, South Korea.
Poultry science
|June 4, 2025
概括
刺激生物 (STB) 补充剂在患有死肠炎 (NE) 的 brojlers 中改善了营养消化能力和肠道健康. STB增强了肠道屏障功能和调节了肠道微生物群,减轻了NE引起的负面影响.
科学领域:
- 动物科学动物科学
- 鸟类营养 鸟类营养
- 肠道健康 肠道健康
背景情况:
- 死亡性肠炎 (NE) 显著损害肉的营养消化能力和肠道健康.
- 肠道屏障完整性,免疫反应和微生物平衡对于肉的表现至关重要.
- 刺激生物 (STB) 是一种潜在的料添加剂,可以改善肠道健康.
研究的目的:
- 调查刺激生物 (STB) 对减轻死肠炎 (NE) 对 brojler 养分消化能力和肠道健康的影响的疗效.
- 评估STB对肠道屏障基因表达 (ZO-1,MUC2,TLR4) 和免疫标记物 (干扰素-γ,异质细胞) 的影响.
- 评估STB对肠道微生物群组成和NE挑战型肉卵囊脱落的影响.
主要方法:
- 一个2x2的因数实验,使用200个Arbor Acres肉接受NE挑战 (菌疫苗过量) 或没有挑战,有或没有0.05%的STB补充剂.
- 测量包括营养消化能力,血液参数 (干扰素-γ,异构体),肠道组织学 (维卢斯高度:密室深度),基因表达 (ZO-1,MUC2,TLR4),便卵囊数和便微生物群分析.
- 数据使用2x2因数设计进行分析,在P < 0.05.05时确定显著性.
主要成果:
- NE挑战降低了营养物质的消化能力,干扰素-γ,异构体,的高度:密室深度,并改变了ZO-1和MUC2基因表达.
- 在NE挑战的 brojlers中,STB补充剂 (0.05%) 增加了总能量消化能力,减少了卵囊流失,并改善了状的高度:密室深度.
- 在第21天,STB降低了骨中的MUC2和TLR4基因表达,并降低了骨中的Muribaculaceae的丰富性.
结论:
- 摄入0.05%STB的食补充剂有效地减轻了 brojlers 中死肠炎的负面影响.
- STB积极调节内微生物群,增强紧密结合蛋白基因表达,并改善营养利用.
- 补充STB是一种可行的策略,可以改善面临死肠炎挑战的 brojlers 的肠道健康和性能.
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