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Monali M Upare¹, Koustubh Mansing Thorawade², Abhay Prakash Mishra³

¹Krishna College of Pharmacy, Karad, Maharashtra 415539, India.

Current opinion in pharmacology

|June 4, 2025

概括

基于脂质的纳米载体 (LBNs) 通过提高抗微生物剂的溶解性,稳定性和透性来改善皮肤感染的局部药物输送. 挑战包括稳定性,监管和制造,但LBN在治疗细菌和真菌感染方面表现有前途.

科学领域:

皮肤病学皮肤病学
纳米技术纳米技术
药品制造药品制造药品制造

背景情况:

皮肤感染是一个重大的全球健康挑战,因抗菌素耐药性 (AMR) 的增加而加剧.
局部药物输送对于治疗皮肤感染至关重要,但在有效性和透性方面存在局限性.
基于脂质的纳米载体 (LBNs) 正在成为皮肤病应用的先进输送系统.

研究的目的:

审查LBNs用于局部治疗皮肤感染的好处和进步.
讨论阻碍皮肤病学中LBN临床应用的挑战.
突出LBNs在打击耐药性皮肤病原体方面的潜力.

主要方法:

对基于脂质的纳米载体 (脂质体,固体脂质纳米颗粒 (SLN),纳米结构脂质载体 (NLCs)) 的当前文献的综述.
分析与局部药物输送相关的LBN特性,包括溶解性,稳定性和释放动力学.
对常见的细菌和真菌皮肤病原体LBN疗效的评估.
确定与LBN配方,稳定性,监管批准和制造相关的挑战.

主要成果:

LBNs增强了抗菌剂的溶解性,稳定性和持续释放.
这些纳米载体促进了更深层次的皮肤透,改善了药物的生物可用性在感染部位.
LBNs对细菌和真菌皮肤感染表现出广泛的活性.
关键的挑战包括配方稳定性 (聚合,氧化),监管差距和可扩展的制造.

结论:

在皮肤感染中,LBN为局部抗微生物治疗提供了显著的优势.
克服稳定性,监管和制造障碍对于临床翻译至关重要.
需要进一步的研究和开发,才能充分实现LBNs在皮肤病学中对抗AMR的潜力.

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