涉及到优先手部姿势代表行动的脑电路
V Piombino1, M D'Alonzo2, F Castro3
1Neurophysiology and Neuroengineering of Human-Technology Interaction Research Unit, Università Campus Bio-Medico di Roma, Rome, Italy; Department of Psychology and Life Sciences, Faculty of Humanities, Charles University, Prague, Czechia.
概括
大脑优先代表指向下/手指向上的手姿势,增强感官运动性能. 这种优势源于一个神经电路,涉及前运动皮质 (PM) 向主要运动皮质 (M1) 投射.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 人类的感官运动性能
背景情况:
- 大脑首选地代表了指向下/手指向上的手姿势.
- 这种超模态表示增强了感官运动性能.
- 底层的皮质电路仍然需要确定.
研究的目的:
- 确定特定的皮质电路,负责指向下/手指向上手部姿势的感觉运动优势.
- 研究皮质脊柱和皮质皮质连接在这种姿势优势中的作用.
- 探索主要运动皮层 (M1) 中的抑制和促进机制.
主要方法:
- 利用跨磁性刺激 (TMS) 用不同的线圈方向 (前后,后中,后前) 来探测不同的皮质电路.
- 应用双脉冲TMS协议来评估皮质内抑制和促进.
- 在标准 (下指/上指) 和反向手姿势中测试皮质脊柱和皮质皮质连接.
主要成果:
- 前后TMS,激活前运动皮质 (PM) 到M1连接,显示在姿势之间皮质脊髓刺激性 (p=0.003) 和MEP (p<0.003) 的显著差异.
- 偏好局部皮质连接的前后TMS也显示出显著的差异 (p=0.042).
- 针对直接皮质脊髓连接的后端介质刺激没有显示姿势偏好;皮质内机制不受影响.
结论:
- 姿势优势与一个神经回路有关,其中涉及到向M1投射的PM皮质.
- 这个电路由前后和前后TMS激活.
- 皮质脊髓唤起的活动提供了关于身体表现和偏好的姿势的神经基础的见解.
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