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对鱼类的毒性敏感性和功能特征进行比较分析

Randel Kreitsberg1, Richard Meitern1, Ciara Baines2

  • 1Institute of Ecology and Earth Sciences, University of Tartu, Liivi 2, 50409, Tartu, Estonia.

Aquatic toxicology (Amsterdam, Netherlands)
|June 4, 2025
PubMed
概括

密切相关的鱼类种类在污染敏感度上表现出显著的差异,这挑战了强烈的毒素反应的强基因信号的想法. 这种变异可能源于对不同生态和生命历史的适应.

关键词:
适应化学品的情况化学耐受性 化学耐受性生态风险评估评估生态风险评估性格特征的演变鱼类生理学 鱼类生理学对有毒物质的敏感性

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...