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聚烯微塑料通过激活循环氧化酶-2信号通路来诱导骨细胞衰老

Lijun Li¹, Yingfeng Su¹, Jian Huang²

¹Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine & Zhejiang Key Laboratory of Mechanism Research and Precision Repair of Orthopaedic Trauma and Aging Diseases, Hangzhou, Zhejiang 310016, China.

Ecotoxicology and environmental safety

|June 4, 2025

概括

聚乙烯微塑料通过引起氧化应激和DNA损伤来损害骨细胞. 阿司匹林可以通过抑制COX2通路来缓解这种微塑料诱导的骨细胞衰老.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
细胞生物学细胞生物学

背景情况:

聚烯微塑料 (MP) 是普遍存在的环境污染物.
它们对关键骨细胞骨细胞的影响尚不清楚.
骨细胞功能对于保持骨健康至关重要.

研究的目的:

研究聚烯微塑料对骨细胞功能的影响.
阐明微塑料诱导的骨毒性背后的细胞机制.
探索针对微塑料诱导的骨损伤的潜在治疗干预措施.

主要方法:

骨细胞暴露于5微米的聚烯微塑料 (100微克/毫升48小时).
评估了细胞毒性,氧化应激 (ROS),细胞循环停止和DNA损伤.
分析了骨细胞信号传递,新陈代谢和循环氧化酶-2 (COX2) 途径.
研究了阿司匹林对微塑料诱导的衰老的影响.

主要成果:

微塑料被骨细胞内化,导致细胞毒性,氧化应激和DNA损伤.
微塑料破坏了骨细胞的信号传递和新陈代谢.
微塑料激活了COX2通路,增加了促炎性细胞因子和骨细胞衰老.
阿司匹林治疗显著减少了微塑料诱导的骨细胞衰老.

结论:

聚烯微塑料通过氧化应激和COX2激活诱导骨细胞衰老.
用阿司匹林准COX2通路可能是防止微塑料诱导的骨损伤的保护策略.
这些发现强调了微塑料的潜在骨质毒性及其对骨健康的影响.

关键词:

循环氧基因酶-2 的作用.骨质细胞是一种骨质细胞.聚乙烯微塑料的微塑料.衰老是一种衰老.

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