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微观边缘干涉对乳头甲状腺癌复发的影响
Hyungju Kwon1, Hyeji Kim1, Hyeonuk Hwang1
1Department of Surgery, Ewha Womans University Medical Center, Seoul, Republic of Korea.
概括
在乳头甲状腺癌 (PTC) 中,微观的积极外科边缘 (PSM) 显著增加了复发风险. 患有微观PSM的患者需要仔细管理和随访,以改善结果.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 阳性手术边缘 (PSM) 发生在约10%的甲状腺癌患者中.
- 宏观PSM表明残留癌症,而显微PSM的影响不太清楚.
- 这项研究侧重于在乳头甲状腺癌 (PTC) 中的显微PSM.
研究的目的:
- 调查微观PSM在PTC中的预后影响.
- 确定微观PSM与瘤复发之间的关联.
主要方法:
- 分析了1495名接受全甲状腺切除 (2009-2023) 的PTC患者.
- 倾向性得分匹配 (1:3) 调整为混.
- 主要终点是5年无复发生存期.
主要成果:
- 在4.5%的患者中发现了微观PSM,与较大的瘤和甲状腺外延伸有关.
- 显微PSM组的5年无复发存活率显着较低 (90.1%对98.2%).
- 微观PSM增加了几乎五倍的复发风险 (HR 4.958).
结论:
- 微观PSM是PTC复发的一个独立风险因素.
- 患有微观PSM的患者需要量身定制的治疗和警的随访策略.
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