高风险尾癌的非瘤切除和生存:国家癌症数据库研究
Sophie H Chung1, Sarah M Schroter2, Kelsey S Romatoski1
1Department of Surgery, Boston Medical Center, Boston, Massachusetts; Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
The Journal of surgical research
|June 4, 2025
概括
经过非瘤切除 (NOR) 的高风险尾腺癌患者的存活率比接受瘤切除的患者要差. 老年患者和早期疾病患者更有可能接受NOR,尽管有指导方针.
科学领域:
- 手术瘤学手术瘤学
- 胃肠道癌症研究研究
- 临床结果分析 临床结果分析
背景情况:
- 附录腺癌指南建议在高风险病例中进行瘤切除术.
- 非瘤切除 (NOR),如尾切除术,有时可以代替.
- 这项研究调查了接受NOR与瘤切除术的高风险尾癌患者的生存结果.
研究的目的:
- 评估非瘤切除 (NOR) 与高风险尾腺癌的存活率之间的关联.
- 为了确定与高风险尾腺癌中NOR相关的患者和疾病特征.
- 为了在这个患者队列中比较NOR和瘤切除术之间的生存率.
主要方法:
- 来自国家癌症数据库的4510名尾腺癌患者 (2010-2019) 的回顾性分析.
- 选择具有高风险特征的患者 (例如,高等级,晚期,积极边缘).
- 倾向性得分匹配 (1:1) 和多变量逻辑回归用于比较NOR和瘤切除组之间的5年生存率.
主要成果:
- 37.6%的高风险患者接受了NOR.
- NOR与年龄较大,黑人种族,社区中心,早期疾病,阳性边缘和没有辅助化疗有关.
- 瘤切除术与与NOR相比显著更高的5年整体存活率相关 (67.5%与60.7%,P<0.0001) 在匹配后.
结论:
- 在高风险的尾腺癌中,非瘤切除 (NOR) 与更差的生存结果有关.
- 老年患者和早期疾病患者不成比例地更有可能接受NOR.
- 遵守瘤切除术指南对于改善高风险尾癌的存活率至关重要.
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