在患有状细胞病的儿童中,血清YKL-40水平升高
Veysi Akbey1, Selma Ünal2, Özlem Tezol1
1Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin, Türkiye.
The Turkish journal of pediatrics
|June 4, 2025
概括
在患有状细胞疾病 (SCD) 的儿童中,YKL-40水平升高,这表明它可能在慢性炎症中起作用. 这些水平可能有助于监测SCD患者的炎症.
科学领域:
- 生物化学 生物化学
- 儿科血液学 儿科血液学
- 炎症研究 炎症研究
背景情况:
- 一种糖蛋白YKL-40与炎症和血管功能障碍有关.
- 状细胞疾病 (SCD) 涉及炎症和内皮功能障碍过程.
研究的目的:
- 在患有SCD的儿科患者中检查血清YKL-40水平.
- 为了在稳定状态下,在血管封闭危机 (VOC) 期间,和健康对照组之间比较SCD儿童的YKL-40水平.
主要方法:
- 血清YKL-40度测定在33名SCD儿童和33名健康对照人群中.
- 患者在稳定状态和,如果适用,在VOC发作期间进行评估.
- 在这些组中,YKL-40水平进行了比较.
主要成果:
- 患有SCD的儿童在稳定状态 (p=0.001) 和VOC发作 (p=0.005) 期间,YKL-40水平明显高于健康对照组.
- 在SCD组中,YKL-40水平在稳定状态和VOC发作之间没有显著差异 (p=0.381).
- 在稳定状态和VOC发作期间的YKL-40水平之间没有发现显著的相关性 (p=0.955).
结论:
- YKL-40可能在状细胞疾病的炎症成分中发挥作用.
- 循环中的YKL-40水平可以作为监测儿科SCD患者慢性炎症的生物标志物.
更多相关视频
08:23Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
10.0K
05:23Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
19.7K
相关概念视频
01:24Chronic Kidney Disease II: Clinical Manifestations
107
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
107
01:27Disorders of Leukocytes
1.2K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.2K
01:49Multiple Allele Traits
35.0K
The Concept of Multiple Allelism
35.0K
01:24Serum Studies: Renal Function Tests
54
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
54
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
64
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
64