睡眠质量和临床前心力衰竭的结果:英国生物库前性队列研究
Fang Zhu1, Joseph J Shearer1, Jungnam Joo2
1Epidemiology and Community Health Branch, National Heart, Lung, and Blood Institute.
The American journal of medicine
|June 4, 2025
概括
睡眠质量差显著增加患临床心力衰竭 (HF) 和死亡率的风险,特别是在女性中. 在临床前HF患者解决睡眠问题可能会改善结果.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 预防心力衰竭对于降低发病率和死亡率至关重要.
- 目前的指导方针侧重于HF的进展,但睡眠对临床前HF结果的影响尚不清楚.
- 这项研究研究了临床前HF的睡眠质量及其与临床HF和死亡率的关联.
研究的目的:
- 检查一大批患有临床前心力衰竭 (A/B阶段) 个体的睡眠质量.
- 评估各种睡眠特征与患临床心力衰竭 (C/D阶段) 或死亡的风险之间的关联.
- 探索睡眠质量对临床结果在临床前HF患者的影响.
主要方法:
- 利用英国生物库数据 (2006-2010) 识别了311,446名临床前高血压患者.
- 评估自我报告的睡眠时间,时间型,失眠,打和白天嗜睡,创建睡眠质量评分.
- 采用具有竞争风险的Cox比例危险模型来分析与临床HF和死亡率的关联,在中位数为12年的随访期间.
主要成果:
- 在5%的参与者中观察到睡眠质量差,并且与女性 (HR 2.03) 和男性 (HR 1.55) 临床HF风险增加有关.
- 在所有睡眠质量类别中,高血压风险与睡眠剥夺有关 (P < .01).
- 在随访期间,发生了超过10,780例临床HF事件和24,996例死亡.
结论:
- 低睡眠质量在临床前心力衰竭中普遍存在,并显著提高了进展到临床心力衰竭和死亡率的风险.
- 患有临床前HF和睡眠质量差的女性的风险特别高.
- 针对临床前HF人群的睡眠质量的干预措施,特别是那些面临贫困的人群,可以减轻不良结果.
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