怀孕期间和怀孕生活方式干预 (INTER-ACT):一种随机对照试验
Annick Bogaerts1, Hanne Van Uytsel2, Lieveke Ameye2
1REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; L-C&Y, KU Leuven Child & Youth Institute, Leuven, Belgium; Faculty of Health, University of Plymouth, Devon, UK.
INTER-ACT生活方式干预措施并没有减少之前过度妊娠体重增加的妇女的妊娠并发症. 然而,在怀孕期间坚持该计划,在两组中都显著降低了并发症风险.
科学领域:
- 生殖健康 生殖健康
- 孕产妇健康 孕产妇健康
- 预防医学 预防医学
背景情况:
- 预孕前的生活方式干预可以减轻怀孕并发症,但在接触女性方面面临挑战.
- 过度的妊娠体重增加是妊娠不良结果的危险因素.
研究的目的:
- 为了评估怀孕期间为健康未来提供辅导 (INTER-ACT) 生活方式干预措施的有效性.
- 评估干预措施对减少有过度妊娠体重增加史的妇女怀孕并发症的影响.
主要方法:
- 一个前性的多中心随机对照试验,涉及分娩后6周内招募的妇女.
- 互动行动的干预包括面对面的指导和电子健康应用程序,重点是营养,体育活动和心理健康.
- 主要结局是妊娠并发症的复合;每组需要250名妇女才能获得统计能力.
主要成果:
- INTER-ACT干预措施没有显著减少妊娠并发症的复合结果 (OR,1.29;P=.23).
- 后期分析显示,在怀孕期间遵守随访与干预组和对照组 (P=0.04和P=0.02分别) 中复合结果风险减半有关.
结论:
- 在之前过度妊娠体重增加的妇女中,INTER-ACT干预措施没有有效降低复合妊娠并发症率.
- 怀孕期间坚持干预措施成为关键因素,显著降低并发症风险.
- 未来的研究应该优先考虑改善坚持和调查生活方式干预措施在各种BMI范围在怀孕前和怀孕期间.
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