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Updated: Sep 19, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Published on: May 30, 2025

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链接器优化在癌症模型中增强了光核酶向化马的效力

Samantha M Meyer1,2, Sandra Kovachka1, Tenghui Wang1,2

  • 1The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, 130 Scripps Way, Jupiter, Florida 33458, United States.

Journal of medicinal chemistry
|June 4, 2025
PubMed
概括

在核酶向仿真体 (RiboTACs) 中优化链接器长度可以提高它们对抗癌细胞的效力. 这项研究表明,在白血病和乳腺癌模型中,RiboTACs有效降低瘤转录,并诱导亡.

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