验证动物命名试验用于诊断最小肝脑病变
A D Cano-Contreras1, J A Velarde-Ruiz Velasco2, F Higuera-de-la-Tijera3
1Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz, Mexico.
Revista de gastroenterologia de Mexico (English)
|June 4, 2025
概括
动物命名测试 (ANT1) 有效地识别了墨西哥肝硬化患者的最小肝脑病变 (MHE). 一个≤15名动物的切断有助于快速查MHE,这是一个复杂的诊断条件.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 神经科学是一个神经科学.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 在临床实践中,诊断最小肝脑病变 (MHE) 是具有挑战性和耗时的.
- 动物命名测试 (ANT1) 提供了一个快速的方法来识别MHE.
研究的目的:
- 验证ANT1在墨西哥肝硬化患者队列中诊断MHE的实用性.
- 在这个群体中确定ANT1的可靠切断点.
主要方法:
- 一项观察性,横截面研究包括199名肝硬化患者和31名对照.
- 使用心理计量肝脏脑病变评分 (PHES) 确认了MHE诊断.
- 所有参与者都接受了ANT1检查,除了那些明显患有肝脏脑病的人.
主要成果:
- 九十名患者 (45.2%) 在PHES的基础上被诊断为MHE.
- ANT1的截止值为≤15名动物,在32.7%的患者中发现了MHE.
- ANT1显示了75%的灵敏度,72%的特异性和73%的诊断准确度 (AUC=0.763).
结论:
- 在常规的临床环境中,ANT1是MHE识别的宝贵工具.
- 在ANT1上命名的≤15只动物的切割值可以用于快速查高风险患者.
- 这种查有助于识别可能需要进一步,更广泛的MHE测试的个人.
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