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维生素C用于新生儿脑病变中的神经保护

Raul Chavez-Valdez1,2, Nazli Kuter3,4, Srishti Jayakumar3,4

  • 1Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. rchavez2@jhmi.edu.

Pediatric research
|June 4, 2025
PubMed
概括

维生素C是一种抗氧化剂,可以防止新生儿缺氧缺血性脑损伤. 本评论讨论了实验因素,如干预时间和解释这些神经保护作用的模型局限性.

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Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
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