克罗辛载荷的Noisome在Paraquat诱导的氧化应激中的抗氧化作用在肺鼠中的抗氧化作用
Anahita Abbasifard1, Ashkan Karbasi2, Akram Oftadeh Harsin3
1Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Cell biochemistry and biophysics
|June 4, 2025
概括
与克罗辛相比,纳米克罗辛可以提供比帕拉克瓦特诱导的肺损伤更好的保护. 这种天然化合物有效地对抗老鼠的氧化压力和毒性,突出其潜在的治疗益处.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品化学 自然产品化学
- 生物医学研究生物医学研究
背景情况:
- 沙夫兰含有克罗辛,一种具有抗氧化特性的天然化合物.
- 帕拉奎特除草剂会导致氧化应激和肺损伤.
- 调查自然化合物对减轻帕奎特毒性的作用至关重要.
研究的目的:
- 评估克罗辛和纳米克罗辛对帕拉克瓦特诱导的氧化应激和小鼠肺部毒性的保护作用.
- 为了比较纳米克罗辛与克罗辛在减轻帕拉克瓦特毒性的疗效.
主要方法:
- 30只雄性Wistar大鼠在7天内口服了帕拉克瓦特 (5毫克/公斤).
- 鼠同时接受了克罗辛或纳米克罗辛 (20毫克/公斤,IP).
- 评估了氧化应激生物标志物 (TAC,TTG,LPO) 和肺纤维化 (氧水平).
主要成果:
- 帕拉奎特的使用增加了脂质过氧化 (LPO) 和氧水平,同时降低了总抗氧化能力 (TAC) 和总醇组 (TTG).
- 与克洛辛相比,纳米克洛辛治疗显著降低了LPO和氧水平,并增加了TAC和TTG.
- 纳米crocin 证明了更大的保护效应,比crocin 对帕拉克瓦特诱导的肺损伤.
结论:
- 纳米crocin 展现出比crocin 更强大的保护作用,防止帕拉克瓦特诱导的肺损伤.
- 纳米克洛辛可能通过调节氧化应激通路来减轻帕拉克瓦特的毒性.
- 纳米crocin显示承诺作为一种治疗剂,以防止帕拉克瓦特诱导的氧化损伤.
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