出生体重和妊娠年龄对中年人的认知功能的影响:博加卢萨心脏研究
Eunsun Gill1, David J Libon2,3, Soo Jung Kang1
1Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, New Orleans, LA, 70112, USA.
BMC neurology
|June 4, 2025
概括
较高的出生体重与更好的中年认知功能有关,特别是在工作记忆和处理速度等领域. 孕期年龄主要影响早产婴儿的认知功能,这表明早期生活因素会影响以后的认知健康.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 发展生物学 发展生物学
背景情况:
- 出生体重和妊娠年龄 (GA) 对中年人的认知功能 (CF) 的长期影响,特别是关于种族差异的长期影响,尚未完全理解.
- 以前的研究已经在中年之前建立了出生体重,GA和CF之间的联系,但对后期生命阶段的数据仍然没有确定性.
研究的目的:
- 调查出生体重,GA和中年人的认知功能之间的关联.
- 检查这些协会中潜在的种族差异.
主要方法:
- 分析了来自博加卢萨心脏研究的1,032名参与者 (平均年龄为48.1岁;67%是白人,33%是黑人).
- 认知功能使用标准化测试对口头情节性记忆,工作记忆,注意力,图形运动处理速度和全球CF进行评估.
- 使用多变量线性回归模型来确定关联,控制相关因素.
主要成果:
- 出生体重增加100克与改善的全球认知功能,工作记忆和图形运动处理速度相关.
- 虽然在种族子组内没有统计学意义 (可能是由于功率限制),但出生体重-CF关联的效果大小在种族群体中是相似的.
- 妊娠年龄作为连续变量没有与CF相关,但早产与更好的认知结果有关.
结论:
- 出生体重似乎影响全球认知功能,持续到中年.
- 妊娠年龄对认知功能的影响在早产的个体中最为显著.
- 这些发现强调了早期生活因素在塑造认知健康轨迹方面的持久作用.
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