在肝细胞癌中,肠道微生物群和微生物群衍生的代谢物之间的交叉关系
Sang Jun Yoon1, Seul Ki Han2, Tae Suk Kim3
1Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea.
Critical reviews in microbiology
|June 5, 2025
概括
本综述探讨了肠道微生物群及其代谢物如何影响肝细胞癌 (HCC) 的发展. 了解肠 - 肝轴为恢复肠道平衡和打击肝癌提供了潜在的治疗点.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 肝细胞癌 (HCC) 是由慢性肝损伤,炎症和纤维化引起的.
- 肠-肝轴越来越多地被认为是其在HCC病变发生过程中的作用.
- 关于将肠道微生物群与HCC联系在一起的特定机制的数据有限.
研究的目的:
- 审查关于肠道微生物群和HCC发育中的代谢物的临床和动物研究.
- 阐明肠道失生症促进肝癌发生的机制.
- 确定涉及微生物驱动HCC促进的特定途径.
主要方法:
- 临床和动物研究的系统审查.
- 对有关肠肝轴和HCC的当前科学文献的分析.
- 专注于肠道失生症的机制和肝癌中的微生物代谢物.
主要成果:
- 肠道失调是促进肝癌发生的一个关键因素.
- 特定的微生物代谢物和途径直接促进HCC的发展.
- 肠肝轴显著影响肝病的进展.
结论:
- 准肠肝轴为HCC提供了潜在的治疗策略.
- 识别有益或有害的微生物菌株可以帮助恢复肠道平衡.
- 对微生物干预的进一步研究可能有助于预防和治疗HCC.
相关概念视频
02:17The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
01:50What is Monogastric Digestion?
75.0K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
75.0K