贾斯帕米德/贾斯普拉基诺利德是由海绵中的Jaspinella (Tectomicrobia) 细菌合成的
Zhenjian Lin1, Kyle Wolf2, Vinayak Agarwal3
1Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Journal of natural products
|June 5, 2025
概括
海洋海绵共生体,包括新发现的jaspinella属,产生强大的防御毒素,如jaspamide. 这一发现扩大了我们对细菌生物多样性和海洋生态系统中自然产品的演变的理解.
科学领域:
- 海洋微生物学 海洋微生物学
- 自然产品化学 自然产品化学
- 进化生物学是进化的生物学.
背景情况:
- 海洋海绵中的共生细菌产生防御性化合物.
- 这些共生的形成,生物多样性和生态作用尚未完全理解.
- 海洋海绵拥有多样化的微生物群落,这些微生物群落是新型生物活性化合物的来源.
研究的目的:
- 在海洋海绵中识别负责产生毒素jaspamide的细菌共生体.
- 为了描述斯巴胺的生物合成基因集群.
- 扩大已知的海绵相关细菌的遗传学多样性及其生态作用.
主要方法:
- 对海绵微生物组的元基因组学分析.
- 鉴定和表征石胺生物合成基因集群 (jas).
- 对Tectomicrobia属的遗传学分析.
主要成果:
- 在两个不同的海绵物种中发现了一种新的细菌属Jaspinella,即Jaspis splendens和Dictyonella sp.
- 贾斯皮内拉含有贾斯基因集群,含有非核糖体合成酶 (NRPS) 和多基合成酶 (PKS) 区域,负责贾斯帕胺生物合成.
- 贾斯皮内拉属于Tectomicrobia,这是一个以前与生产防御化合物的海洋海绵共生体无关的类,扩大了其已知的植物遗传和生态范围.
结论:
- 贾斯皮内拉代表了一种新的海绵共生体属,能够产生强有力的毒素jaspamide.
- 在海洋海绵中发现的贾斯皮内拉扩大了Tectomicrobia的已知的基因学多样性.
- 这项研究增强了我们对海洋环境中防御性化合物和共生关系的演变的理解.
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